Computational Chemistry Research Scientist (Computational Drug Design) Job at Vertex Pharmaceuticals, Boston, MA

  • Vertex Pharmaceuticals
  • Boston, MA

Job Description

Vertex Pharmaceuticals seeks a computational chemist to advance drug discovery through molecular modeling, cheminformatics, and AI-enabled design methods. The role involves collaborating with interdisciplinary teams to identify and optimize drug candidates while contributing to the expansion of computational chemistry capabilities.

Responsibilities

  • Apply computational chemistry methods to accelerate drug candidate discovery and optimization
  • Leverage physics-based methods, generative models, and machine learning to design chemical entities
  • Collaborate with chemists, structural biologists, and project teams on hit and lead identification
  • Assess and develop new computational methodologies, create workflows, and share best practices
  • Identify opportunities to enhance R&D capabilities through cross-functional collaboration

Requirements

  • Ph.D. in Computational Chemistry or equivalent degree
  • 0-3 years of relevant computational drug design experience
  • Expertise in structure-based drug design methods
  • Proficiency in Python scripting and programming
  • Experience with molecular modeling software (commercial and open-source)
  • Demonstrated ability to apply modern AI capabilities to design and discovery workflows
  • Strong communication and presentation skills

Compensation: $108,000 - $162,000 base

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