Senior Scientist II, Computational Chemistry Job at Revolution Medicines, Redwood City, CA

  • Revolution Medicines
  • Redwood City, CA

Job Description

Revolution Medicines seeks a Senior Scientist II in Computational Chemistry to lead drug discovery programs using computational, cheminformatics, and data science approaches. The role involves designing and optimizing novel therapeutics targeting RAS-addicted cancers through advanced modeling and strategic collaboration with multidisciplinary teams.

Responsibilities

  • Lead computational chemistry strategy on multidisciplinary discovery teams and drive compound design from hit finding through optimization
  • Design and implement virtual screening workflows using structure-based and ligand-based computational methods
  • Develop compound prioritization strategies and risk-mitigation approaches for medicinal chemistry partners
  • Collaborate with Advanced Analytics to create, validate, and advocate AI/ML models for molecular design
  • Devise strategies to enhance hit-finding capabilities for novel protein and protein-protein interaction targets

Requirements

  • Ph.D. in computational chemistry or related field
  • 5+ years computational chemistry experience in biotechnology or pharmaceutical industry
  • Demonstrated track record of impactful drug discovery contributions
  • Expert knowledge of docking, virtual screening, and protein-ligand analysis methods
  • Experience integrating SAR, structural biology, biophysical, and ADME/PK data
  • Proficiency with physics-based modeling and free energy calculation methods
  • Experience implementing and evaluating AI/ML workflows for molecular design

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